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Tuesday, September 8, 2009

Amyloidosis - Conditions Caused by Chronic Kidney Failure

Micrograph showing amyloid deposition (red fluffy material) Image Source: Wikipedia.com

• Is a condition where a waxy protein is deposited in the soft tissues, bones and joints.
• This protein, beta-2-microglobulin (B2m) is normally found on the surfaces of cells and in body fluids.
• When the kidneys fail, B2m serum levels increase, it enters the tissues, and is converted to amyloid.
• Deposits of amyloid can cause carpal tunnel syndrome (painful compression of a key nerve in the wrist.

• On x-ray, amyloid is found in about:
     • 20% of patients after 10 years of hemodialysis
     • 30-50% after 15 years
     • 80-100% after 20 years or more
• Synthetic dialyzer membranes remove more B2m than membranes made of cellulose.
• Longer and/or more frequent treatments also remove more B2m.

Amyloidosis - Conditions Caused by Chronic Kidney Failure - Related Hemodialysis Article


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