Effect of hemodialysis and peritoneal dialysis on redox status in chronic renal failure patients: a comparative study

ObjectiveTo investigate the effects of hemodialysis (HD) and periotoneal dialysis (PD) on oxidative stress in chronic renal failure patients (CRF).

Methods: 20 HD patients and 20 PD patients were compared with 20 end stage renal failure patients (CRF).

Results: Thiobarbituric acid reactive substances (TBARS) values were elevated in HD and decreased in PD compared to CRF (P<0.05). TBARS-VLDL and TBARS-HDL2 were decreased in HD and PD, compared to CRF (p<0.05). TBARS-LDL were higher in HD compared to CRF (p<0.05). No significant difference in TBARS- HDL3 values between the three groups. Carbonyls were increased in HD (p<0.05) and PD (p<0.01) compared to CRF. Plasma superoxide dismutase activity (SOD) was decreased in HD compared to CRF and PD (P<0.05). Glutathion peroxidase activity (GSH-Px) was decreased in HD and PD (P<0.005), compared to CRF. Decrease in catalase activity was noted only in PD compared to CRF (P<0.05). An increase in nitric oxide was noted in HD compared to CRF (p<0.05). Albumin concentrations were higher in HD and PD compared to CRF (P<0.001). READ MORE

Effect of hemodialysis and peritoneal dialysis on redox status in chronic renal failure patients: a comparative study - Related Hemodialysis Article